Hepcidin is initially synthesized as an 84-amino acid preprohormone (preprohepcidin) which undergoes sequential cleavages to form the active, mature hormone. The first cleavage by signal peptidase …

Jul 28, 2022 · Hepcidin is a hormone that regulates how your body uses iron. It controls how much iron is available for essential body functions, like making hemoglobin and red blood cells.

Apr 17, 2023 · Hepcidin is a peptide hormone produced in the liver that plays a crucial role in iron homeostasis. Iron is an essential part of oxygen transport within the body and is present in …

Aug 2, 2025 · Hepcidin is a hormone primarily produced by the liver, acting as a central regulator of iron in the body. Its discovery marked a significant advancement in understanding how the body …

Jun 9, 2016 · Hepcidin pharmacology is an active field with a number of drugs in the pipeline, including hepcidin agonists for the treatment of IO, and hepcidin antagonists for the treatment of iron restriction …

Jul 17, 2024 · Hepcidin controls iron concentration in blood plasma as well as organismal iron storage. The hormone acts by impeding iron delivery to plasma from iron-absorbing duodenal enterocytes, …

Because of its critical role in iron homeostasis and the pathogenesis of iron disorders, hepcidin has emerged as a promising drug target. Here we review the biology of hepcidin and highlight various …

Hepcidin is an iron-regulating peptide hormone made in the liver. It controls the delivery of iron to blood plasma from intestinal cells absorbing iron, from erythrocyte-recycling macrophages, and from iron …

Jul 20, 2025 · Hepcidin is a hormone produced by the liver that directs how your body absorbs, stores, and uses iron. It acts as the master regulator of iron in the bloodstream, functioning like a gatekeeper …

Jan 27, 2023 · Hepcidin, secreted by hepatocytes, functions by controlling the activity of the cellular iron exporter ferroportin, which delivers iron to plasma from intestinal iron absorption and from iron stores.