Carboplatin is an organoplatinum antineoplastic alkylating agent used in the treatment of advanced ovarian carcinoma.9Carboplatin has a long duration of action as it is given every 4 …

Carboplatin exhibits slower aquation (replacement of CBDCA by water) and thus slower DNA binding kinetics, although it forms the same reaction products in vitro at equivalent doses with …

The platinum-based anti-cancer drugs, including cisplatin 8, carboplatin 9, and oxaliplatin 10, with manifest therapeutic effects and well-defined mechanisms of action, are widely used in the clinic.

Its mechanism of action is through binding within and between DNA strands, thereby inhibiting protein synthesis in a cell cycle phase–nonspecific manner. Carboplatin is eliminated in the urine.

Carboplatin undergoes intracellular activation to form reactive platinum complexes which are believed to inhibit DNA synthesis by forming inter-strand and intra-strand cross-linking of DNA …

Aug 14, 2025 · Carboplatin works primarily by forming interstrand DNA cross-links, causing cell death through inhibition of DNA replication and transcription. 1 This platinum-based compound …

Jun 19, 2023 · Carboplatin undergoes activation inside cells and forms reactive platinum complexes that cause the intra- and inter-strand cross-linkage of DNA molecules within the …

This short review focuses on the reason for the unusual stability of carboplatin in its aqueous ready-to-use infusion solution, describes the reactions of the drug with biologically common …

Carboplatin is a derivative of cisplatin; it has a similar mechanism of action, but differs in terms of structure and toxicity. It was approved by the FDA in the 1980s and since then it has been …

Jul 17, 2024 · In summary, carboplatin operates through a meticulously structured mechanism that involves entering cancer cells, undergoing activation, binding to DNA, and ultimately …