Developing drugs against multi-protein complexes is traditionally challenging. In this study, we develop molecular COUPLrs, dual cysteine-reactive small molecules, that can engage complexes across the ...
In vivo CAR T-cell therapy is appealing because it removes many of the cumbersome steps of conventional cellular therapy. Yet, because treatment administers a delivery system and the CAR T-cell ...
Pancreas Center, National Clinical Research Center for Cancer, State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Key Laboratory of Digestive Cancer, ...
Cancer Discov (2026) 16 (10): OF1.
Cancer Discov (2026) 16 (10): OF1.
Cancer Discov (2026) 16 (10): OF1.
AbstractSingle-cell RNA sequencing (scRNA-seq) has revolutionized our understanding of cancer. However, identifying meaningful disease states from single-cell data remains challenging due to the ...
Summary. Neoadjuvant chemoimmunotherapy improves outcomes in resectable non–small cell lung cancer, yet pathologic response incompletely predicts the durability of benefit. Spatial profiling using ...
Copyright held by the owner/author(s).
Copyright held by the owner/author(s). This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International ...
Abstract. Advances in cancer prevention, early detection, and treatment have led to substantial improvements in cancer outcomes in the United States over the past several decades. Despite this ...
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