Neuroscientist Roya Huang tells us about their experience of publishing in the eLife Model. Roya Huang is a Postdoctoral Fellow in the Department of Molecular and Cell Biology, University of ...

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eLife has changed its editorial process to eliminate accept/reject decisions after peer review and instead provide readers with richer and more nuanced assessments of articles. eLife changed its ...

Crystal structures of γ-protocadherin cell-cell recognition dimers reveal the determinants of clustered protocadherin homophilic specificity and cis interaction region structures alongside mutagenesis ...

Cryo-EM structures of 70S•RelA ribosome complexes reveal how cognate deacyl-tRNA activates RelA.

where ΔG (γ = 0) is the free energy difference at zero tension, γ the membrane tension and ΔA the in-plane cross sectional area change associated with channel opening (Haswell et al., 2011). Thus, ...

Cryo-electron tomography, reconstitution, and electrophysiological data show that a fundamental function of Munc13-1 is to bridge synaptic vesicles to the presynaptic plasma membrane.

The structure of the calcium channel Orai in an open conformation reveals a dilated pore and gives insight into mechanisms of ion permeation and calcium selectivity.

To control reaching, the nervous system must generate large changes in muscle activation to drive the limb toward the target, and must also make smaller adjustments for precise and accurate behavior.

Osteoporosis most often treated by reducing bone resorption as there are limited choices of medication that are anabolic for bone. Previous studies have suggested that the Notch signaling pathway ...

Inner ear cochlear spiral ganglion neurons (SGNs) transmit sound information to the brainstem. Recent single cell RNA-Seq studies have revealed heterogeneities within SGNs. Nonetheless, much remains ...

This is a thorough, beautiful and compelling study of the flagellar structure of the choanoflagellate S. rosetta as reconstituted by cryo-electron tomography (now one of the handful of eukaryotic ...