An elegant collaboration between researchers in the UK's two core-funded Medical Research Council Research Institutes, the Laboratory of Medical Sciences (LMS) in London and the Laboratory of ...

A single molecule of DNA (not directly visible) is captured using microscopic beads (the large circles). Each of the red, green or yellow dots moving between the beads represent a FANCD2I-FANCI ...

The specific DNA repair pathway affected is predictive of the kinds of mutations, the tumor drug sensitivity, and the treatment outcome. The study of rare inherited DNA repair disorders, such as ...

The ‘heart’ of the Fanconi anemia core complex, composed of FANCB-FANCL-FAAP100 (now FANCX) proteins, allows the rest of the core complex to assemble, and is necessary for downstream DNA repair.

Particle therapy, including proton and carbon ion radiotherapy, represents a major advancement in cancer treatment due to its ...

Throughout the course of our lives, DNA can break in response to natural and environmental factors. However, our bodies have dedicated enzymes and pathways which can repair our broken DNA back ...

A research team has successfully identified a novel DNA damage repair pathway in human cells. This study is the first to discover that proteins present in the nuclear membrane of cells directly ...