TenSixty Biosciences employs an innovative AI-enhanced multi-omics discovery framework to enable the development of next-generation antibody-drug conjugates (ADCs). This integrated approach identified ...
Abstract. Leucine-rich repeat-containing protein 15 (LRRC15) is a transmembrane protein involved in cell-cell and cell-extracellular matrix interactions. It is overexpressed in tumors of mesenchymal ...
Abstract. The overexpression of HER3 in solid tumors is associated with poor prognosis. Therapies developed to target HER3-mediated signaling are often associated with resistance over time, ...
Abstract 2395: DXC011, a novel dual-payload antibody-drug conjugate targeting folate receptor alpha.
Abstract. Folate Receptor alpha (FRα) is highly expressed in epithelial ovarian cancer and selected solid tumors, making it an attractive target for antibody-drug conjugates (ADCs). Although an ...
Abstract. The regulation of epithelial (E) and mesenchymal (M) states requires orchestrated adaptation at the epigenomic level. The 3D genome hierarchical orders, together with chromatin accessibility ...
AbstractBackground:. Urothelial carcinoma (UC) affects over 600,000 patients worldwide annually, with the incidence rate increasing over the past decade. Metastatic urothelial carcinoma (mUC) has a ...
Abstract. PD-L1 is an established immunotherapy target highly expressed in various solid tumors, while B7-H3 is another extensively investigated target overexpressed on a wide range of tumor cells.
Marilyn Hammer, Robin Lally, Barbara Halpenny, Hajime Uno, Ijeoma Eche-Ugwu, Whitney Posada, Inga Van Wieren, Alexi Wright, Ayodeji Adeniji, Sarah Alzahid, Lauren A ...
Abstract. Regulatory T cells (Tregs) have long been appreciated as a key suppressive cell type that limits anti-tumor immunity, yet it has been challenging to find an effective approach to target this ...
AbstractBackground:. Colorectal cancer is highly heterogeneous, exhibiting diverse tumor characteristics. However, studies focusing on the epithelial cell compartment remain limited. Here, we aimed to ...
Cancer Res (2024) 84 (7_Supplement): ND08. The glycosphingolipid GD2 is a cell membrane component of a limited number of normal tissues including nerve cells, melanocytes or lymphocytes. However, in ...
Background: GDF15 is overexpressed in solid tumors, with immunosuppressive effects on dendritic cells (DCs), T cells and myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment. AZD8853 ...
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