Abstract. Leucine-rich repeat-containing protein 15 (LRRC15) is a transmembrane protein involved in cell-cell and cell-extracellular matrix interactions. It is overexpressed in tumors of mesenchymal ...
AbstractBackground:. Urothelial carcinoma (UC) affects over 600,000 patients worldwide annually, with the incidence rate increasing over the past decade. Metastatic urothelial carcinoma (mUC) has a ...
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NOTICE: This notice serves to inform the reader that, in 2023, AACR received a donation by Pfizer of the rights to royalties from the sale—within the United States—of Bavencio (avelumab), a ...
Abstract. The overexpression of HER3 in solid tumors is associated with poor prognosis. Therapies developed to target HER3-mediated signaling are often associated with resistance over time, ...
Abstract. The regulation of epithelial (E) and mesenchymal (M) states requires orchestrated adaptation at the epigenomic level. The 3D genome hierarchical orders, together with chromatin accessibility ...
Abstract. PD-L1 is an established immunotherapy target highly expressed in various solid tumors, while B7-H3 is another extensively investigated target overexpressed on a wide range of tumor cells.
Abstract. Regulatory T cells (Tregs) have long been appreciated as a key suppressive cell type that limits anti-tumor immunity, yet it has been challenging to find an effective approach to target this ...
AbstractBackground:. Colorectal cancer is highly heterogeneous, exhibiting diverse tumor characteristics. However, studies focusing on the epithelial cell compartment remain limited. Here, we aimed to ...
TenSixty Biosciences employs an innovative AI-enhanced multi-omics discovery framework to enable the development of next-generation antibody-drug conjugates (ADCs). This integrated approach identified ...
Background: GDF15 is overexpressed in solid tumors, with immunosuppressive effects on dendritic cells (DCs), T cells and myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment. AZD8853 ...
In vivo CAR T-cell therapy is appealing because it removes many of the cumbersome steps of conventional cellular therapy. Yet, because treatment administers a delivery system and the CAR T-cell ...
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