Ribosome heterogeneity is a paradigm in biology, pertaining to the existence of structurally distinct populations of ribosomes within a single organism or cell. This concept suggests that structurally ...

Cell-free protein synthesis (CFPS) harnesses the molecular machinery of living cells in an open in vitro environment to produce proteins without the constraints of cell viability. Derived from crude ...

A novel study uncovers how a subtle chemical tweak transforms the naturally occurring phytotoxin into a powerful molecular glue, 12-deoxyfusicoccin (12-dFC), that locks 14-3-3 proteins onto the ...

The research field of 'cellular IRESes' lay dormant for decades, as there was no uniform standard of reliable methods for the clear characterization of these starting points for the ribosome-mediated ...

Scientists have developed a powerful new technique that allows them to observe how individual cells manufacture proteins during aging, offering an unprecedented glimpse into the hidden molecular ...

It's known as biology's central dogma: All living organisms' genetic information is stored in DNA, which is transcribed into RNA, which is translated into proteins that perform nearly all essential ...

Collagen, the protein that builds skin, bones, tendons and organs, exists inside cells as a liquidlike droplet rather than ...

The yeast Kluyveromyces lactis (K. lactis) could become a highly productive, sustainable, cost-effective energy source for cell-free protein synthesis (CFPS) as biopharmaceutical manufacturers strive ...

Origami masters turn simple sheets of paper into ornate sculptures. In the origami of life, our cells must fold proteins into ...

Peptide-based signaling systems continue to occupy a central role in modern biochemical inquiry, particularly in areas concerned with extracellular matrix (ECM) dynamics and structural protein ...