Dr. Thomas Lufkin and his colleagues at Mount Sinai School of Medicine have discovered that Dlx genes, the mammalian counterparts of the fruit fly Distal-less (Dll) gene, are required for normal ...

Retinoic acid (RA) was first implicated as a signalling molecule on the basis of its teratogenic effects on limb patterning. Studies in chick using treatment with RA or RA receptor antagonists ...

Scientists have created a spatial atlas of the incredible process of human limb development, including steps that show digits emerging from a bud as cells recede, instead of growing outward. With ...

Scientists reveal unprecedented insights into human limb development, including the many intricate processes that govern their formation. Human fingers and toes do not grow outward; instead, they form ...

A new study gives insight into how limb development evolved in vertebrates. The findings identify a gene that plays a central role in the evolution of limb development in vertebrates. By manipulating ...

Scientists at EPFL have created a scalable 3D organoid model that captures key features of early limb development, revealing how a specialized signaling center shapes both cell identity and tissue ...

Background Limb asymmetries have been identified as a significant predictor of injury risk. However, the natural boundaries of variation in a non-injured population using clinically relevant and ...

During early development, the embryo builds the body's organs by exchanging chemical signals between different cell types. When developing limbs, a thin band of skin cells at the limb’s surface, ...