Nanowerk

Mutation: Types, Causes, Effects on Genes and Proteins, and Role in Disease

In simple terms: a mutation is a stable change in genetic sequence that can be copied when cells or viruses replicate. Most mutations have no detectable effect, some contribute to disease, and a small ...
ascopubs.org

Notch1 mutations to define a subgroup of adenoid cystic carcinoma (ACC): Tumor stage, propensity to bone and liver metastasis, risk of relapse, and overall survival.

Comparison of two large, genetically and clinically annotated head and neck cancer (HNC) cohorts (TCGA, CHGC) and differential treatment effects on TP53 mutated, as well as oral cavity cancers. This ...
Medical Xpress

Somatic mutations with inherited germline variation discovered

A team of 87 researchers from multiple institutions led by the University of Michigan School of Public Health have published a paper in Science Advances—"The genetic determinants of recurrent somatic ...
ascopubs.org

Notch1 mutations in head and neck adenoid cystic carcinoma (HNAdCC) may define an aggressive genetic subtype.

Target volume delineation in locally advanced squamous cell carcinoma of the head and neck (SCCHN) using FDG-PET/CT images post-induction chemotherapy (IC). This is an ASCO Meeting Abstract from the ...