Nature

Efficient cross-trait penalized regression increases prediction accuracy in large cohorts using secondary phenotypes

The CTPR algorithm estimates all SNP effects for the primary trait of interest via a new multivariate penalized least-squares method utilizing information from individual-level data and/or summary ...
Nature

A closer look at cross-validation for assessing the accuracy of gene regulatory networks and models

Cross-validation (CV) is a technique to assess the generalizability of a model to unseen data. This technique relies on assumptions that may not be satisfied when studying genomics datasets. For ...