It's no coincidence that our bodies feel a little creakier as we age. The trillions of cells that make up our skeleton age too, and some change in ways that weaken the very structure of our bones.

Bone tissue is a complex structure, consisting of mineralized collagen fibers and a variety of non-collagenous proteins, including proteoglycans such as biglycan and decorin. These proteoglycans ...

A recent study has uncovered the essential roles of two proteoglycans, biglycan and decorin, in maintaining bone mass, water retention, and bulk/in situ mechanical competence. Through the use of ...

Researchers uncover a redox-regulated mechanism that determines whether bone fractures heal or progress to nonunion ...

Bone health is a critical aspect of overall well-being, particularly for women. Bones provide structural support, protect vital organs, and allow for mobility. However, as women age, the risk of ...

As we age, the health of our bones becomes increasingly important. Osteoporosis, a condition characterized by weakened bones, affects millions, leading to fractures and reduced quality of life. Among ...

Bones consist of an extracellular organic matrix housed in inorganic mineral crystals. The organic matrix is mainly comprised of collagen type 1 amongst other proteins. Bones contain marrow and ...

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