In this collection, we highlight papers reporting structural insights into amyloid fibrils associated with neurodegenerative and systemic diseases as well as functional amyloids that were obtained ...

Solving the structure of an amyloid protein gives new insight into limb-girdle muscular dystrophy type 3 (LGMD D3) and functional protein aggregation. LGMD D3 is a rare disease characterized by slow ...

Structural pathways of the brain facilitate functional communication, and their disruption in preclinical Alzheimer’s disease may reflect network vulnerability and compensatory brain maintenance.

Researchers use microscopy to chart amyloid beta's underlying structure and yield insight into neurodegenerative disease. Amyloid-beta (A-beta) aggregates are tangles of proteins most notably ...

The tiny protein known as transthyretin can cause big problems in the body when it misfolds after secretion. While healthy transthyretin moves hormones through blood and spinal fluid, misfolded ...

Amyloid-beta (A-beta) aggregates are tangles of proteins most notably associated with neurodegenerative diseases such as Alzheimer's. Despite its constant stint in the limelight, however, researchers ...

Prof. Liu Cong from the Shanghai Institute of Organic Chemistry of the Chinese Academy of Sciences, along with collaborators, has revealed the high-resolution structures of amyloid fibrils directly ...

This is a preview. Log in through your library . Abstract Amyloid-β (Aβ) fibrils exhibit self-propagating, molecular-level polymorphisms that may contribute to variations in clinical and pathological ...

Alzheimer's disease (AD) is a debilitating incurable disease that affects millions of patients worldwide. Deposits of amyloid beta (Aβ) amyloid in the brain is key to AD pathology at early stages.

A new biophysical study why apoE and other apolipoproteins co-deposit with amyloids and provides a structural basis for understanding how apolipoproteins modulate amyloid growth and proliferation in ...

Millions of people carry early signs of Alzheimer’s disease in their brains years before they forget a name or lose track of ...

Limb-girdle muscular dystrophy type 3 (LGMD D3) is a rare disease causing progressive muscle weakness, caused by point mutations in the hnRNPDL-2 protein. A member of the RNA-associated ...